Work

Bladder masses simulating neoplasia in chronic granulomatous disease: Diagnostic challenges and spontaneous regression

Year: 2025

Type: article

Abstract: Chronic granulomatous disease (CGD) rarely involves the lower urinary tract, and bladder mass-like lesions are exceptionally uncommon. We report a 23-year-old male with CGD who presented with gross hematuria and multiple large papillary bladder masses on imaging and cystoscopy. Cold-cup biopsies suggested papillary urothelial proliferation but were inconclusive due to limited sampling. Remarkably, repeat cystoscopy and MRI one month later showed complete resolution of all lesions. This case highlights the potential for CGD-related reactive or inflammatory changes to mimic neoplasia and emphasizes the importance of cautious interpretation and short-interval reassessment in such patients.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2025.103312

Authors: Mehdi Dadpour, Niloofar Soleimanifard, Sobhan Alishah, Miaad Chalaki

Institutions: Shahid Beheshti University, Shahid Beheshti University of Medical Sciences, Iran University of Medical Sciences, Hasheminejad Kidney Center

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,160