Association between intermittent hypoxemia and COVID-19 related isolation and pulmonary outcomes through 2 years of age in infants born preterm
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Intermittent hypoxemia events (IH) in preterm infants may alter airway function manifesting as childhood wheezing. OBJECTIVE: Characterize the relationship between IH (first month of life) and wheezing through 12/24 months corrected age. STUDY DESIGN: IH < 80% and <90% and number of wheezing episodes were documented in infants <31 weeks gestation discharged prior to and during COVID-19 social isolation. RESULTS: A greater % time with hypoxemia was associated with increased rates of wheezing through 12 months in infants discharged during COVID-19, (IRRs ranging from 1.07 to 1.32, IH < 80 and 90%, all p < 0.05) and through 24 months in infants <28wks GA discharged during COVID-19 isolation (IRRs, 1.03-1.25, IH < 80 and 90%, all p < 0.05). CONCLUSION: Associations were seen between IH and wheezing at 12 and 24 months of age predominantly in infants discharged during COVID-19 isolation. No associations were seen through 12 months corrected age in infants discharged during the Pre COVID-19 epoch.
Source: Journal of Perinatology
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,790
OpenAlex ID: W4417107299