Year: 2025
Type: article
Abstract: Traditionally linked to motor control and motivation, the basal ganglia, particularly the nucleus accumbens (NAc), are now recognized as central to sleep-wake regulation. Rodent studies highlight the NAc as a hub where motivation, arousal, and sleep homeostasis converge, mediated by D1- and D2-MSN activity. This review examines its organization and circuits, emphasizing roles in vigilance, valence, and associative learning, and exploring emerging hypotheses on its contribution to sleep-related cognition and disorders.
Source: npj Biological Timing and Sleep
Authors: Fares J. P. Sayegh, Patricia Bonnavion
Institution: Université Libre de Bruxelles
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,590
Award: G7290981483
OpenAlex ID: W4417111864