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Efficacy and Safety of Combined Autologous Blood and Minocycline Pleurodesis for Intractable Pneumothorax in High‐Risk Non‐Surgical Patients: A Case Series

Year: 2025

Type: article

Abstract: Pneumothorax in patients with interstitial lung disease (ILD), severe COPD, or other significant comorbidities poses a serious therapeutic challenge, especially when surgery is contraindicated. We report a case series of 22 high-risk patients with intractable secondary spontaneous pneumothorax (SSP) managed with combined autologous blood and minocycline pleurodesis. This bedside, sequential and non-mixed protocol terminated persistent air leak without major complications or recurrence during a 6-month follow-up. Our findings suggest that this simple and accessible approach may serve as a valuable non-surgical alternative in medically inoperable patients.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.70430

Authors: Eitetsu Koh, Yasuo Sekine

Institution: Tokyo Women's Medical University Yachiyo Medical Center

Language: English

Topic: Pleural and Pulmonary Diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,130