Surface expression of antitoxin on engineered bacteria neutralizes genotoxic colibactin in the gut
Year: 2025
Type: article
Source: Nature Microbiology
Authors: Shaobo Yang, Zongqi Wang, Chengyuan Fang, Mengdi Yang, Saleh Khawaled, Shanna Bonanno, Neel S. Joshi, Yun Wei, Ke Zhang, Valeria Márquez-Pellegrin, Ming Guan, Songqi Zhang, Anna Clara Bader, Ningyuan Ye, Amber E. Haley, Michael K. Dame, Jason R. Spence, Xuesong He, James G. Fox, Ömer H. Yilmaz, Yatrik M. Shah, Rizwan Romee, Jiahe Li
Institutions: Northeastern University, Dana-Farber Cancer Institute, University of Michigan, Third Affiliated Hospital of Harbin Medical University, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Michigan Medicine, The Forsyth Institute, Beth Israel Deaconess Medical Center, Harvard University, U-M Rogel Cancer Center
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: green
Awards: G4179743794, G4358906222, Programming Indigenous Gut Bacteria to Prevent Colorectal Cancer Induced by Microbial Carcinogen, Understanding and Harnessing Microbial Reprogramming to Combat Carcinogenic Colibactin in Colorectal Cancer, Control of iron absorption by intestinal HIF2 in iron and hematological disorders, The role of HIF2alpha in colon carcinogenesis, Targeting a human gut bacterial genotoxin via engineered commensal bacteria
OpenAlex ID: W4417112950