Year: 2025
Type: article
Abstract: is developed for initiating the key β-scission step. Importantly, the glycosyl donors are bench-stable and readily available, addressing the issues associated with previous donors. Furthermore, this method offers an attractive strategy for the direct synthesis of drug-sugar conjugates and therapeutic agents. Mechanistic experiments and density functional theory (DFT) calculations provide strong support for the proposed reaction mechanism.
Source: Nature Communications
Authors: Xiang-Yu Ye, Shiqing Huang, Shuai Guo, Guanjie Wang, Wen-Xin Lv, Yonggui Robin Chi
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $6,990
Funders: National Research Foundation, National Research Foundation Singapore, Ministry of Education - Singapore, Nanyang Technological University, National Natural Science Foundation of China, Guizhou University, Ministry of Education, India, Department of Education of Guizhou Province, National Key Research and Development Program of China, Project 211
OpenAlex ID: W4417115305