Mechanical Stiffness Influences the Response of Human Uterine Fibroid Cells to Hormonal Treatments
Year: 2025
Type: article
Abstract: Uterine fibroids (UFs), the most common gynecologic tumors in reproductive-age women, are characterized by the accumulation of extracellular matrix (ECM), which leads to increased stiffness. The stiffness can transfer mechanical signals from the ECM to the intracellular environment through a process called mechanotransduction, consequently altering the biological behavior of the cell. UFs are estrogen and progesterone-dependent, with hormonal fluctuations influencing their growth and development. Consequently, the emphasis in medical treatment development has been on options that target steroid hormones, including GnRH agonists/antagonists, aromatase inhibitors, and anti-progestins. However, there has been limited understanding of how mechanical stiffness influences the progression of UFs and their cells’ response to medical treatments. This work aimed to assess the impact of stiffness on UFs cell growth and on their responsiveness to hormone and anti-hormonal treatments. Our results showed that increased stiffness enhances proliferation and ECM accumulation in UF cells, and that the mechanical environment influences the response of these cells to both hormone and anti-hormone treatments. These findings offer valuable insights for understanding UF pathogenesis, racial disparity as well as improving UF treatment strategies, emphasizing the importance of considering the mechanical microenvironment in clinical approaches.
Source: Reproductive Sciences
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,090
OpenAlex ID: W4417123712