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Comparison of Activation Techniques for the Identification of Nitazene Analogs Using the NIST/NIJ Data Interpretation Tool

Year: 2025
Type: article
DOI: 10.1002/rcm.70004
Language: English
Subfield: Spectroscopy
Field: Chemistry
Open Access status: closed
Award: PURPOSE: THE PURPOSE OF THIS GRANT TO INCREASE THE UNDERSTANDING OF MASS SPECTRAL FRAGMENTATION PATTERNS FOR AN EMERGING CLASS OF SYNTHETIC OPIOIDS NITAZENES. THIS IS OF IMPORTANCE TO THE FORENSIC SCIENCE, CRIMINAL JUSTICE, AND PUBLIC HEALTH SECTORS.ACTIVITIES TO BE PERFORMED: THIS PROJECT WILL MEASURE A SERIES OF NOVEL NITAZENE COMPOUNDS WITH MULTIPLE FORMS OF MASS SPECTROMETRY. FOR EACH TYPE OF MASS SPECTROMETRY USED, THE RESULTING SPECTRA WILL BE USED TO IDENTIFY COMMON FRAGMENTATION PATHWAYS ACROSS THE COMPOUND CLASS, ENABLING IDENTIFICATION OF DIAGNOSTIC IONS AND SHARED FRAGMENTATION MECHANISMS. THIS INFORMATION WILL THEN BE SUMMARIZED AND PROVIDED TO THE SCIENTIFIC COMMUNITY. EXPECTED OUTCOMES: THE RESEARCHERS ARE DEVELOPING AN INTIMATE KNOWLEDGE OF THE MASS SPECTRAL FRAGMENTATION PATHWAYS AND DIAGNOSTIC IONS THAT ARE COMMON FOR NEW SYNTHETIC OPIOIDS FROM THE NITAZENE CLASS. THIS WORK WILL ULTIMATELY RESULT IN (1) AN IN-DEPTH UNDERSTANDING OF THE FRAGMENTATION MECHANISMS OF NITAZENES WHEN ANALYZED BY GAS CHROMATOGRAPHY MASS SPECTROMETRY, (2) AN IN-DEPTH UNDERSTANDING OF THE FRAGMENTATION MECHANISMS OF NITAZENES WHEN ANALYZED BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC-MS/MS) OR DIRECT ANALYSIS IN REAL TIME MASS SPECTROMETRY (DART-MS), AND (3) A BETTER UNDERSTANDING OF THE ABILITY TO TRANSLATE LIBRARIES AND SEARCH TOOLS DEVELOPED FOR DART-MS TO LC-MS/MS. INTENDED BENEFICIARIES: THE DATA GENERATED FROM THIS RESEARCH WILL DIRECTLY BENEFIT THE FORENSIC SCIENCE COMMUNITY, WHO NEEDS RESOURCES LIKE THIS TO BETTER IDENTIFY NEW COMPOUNDS IN THE ILLICIT DRUG SUPPLY. RAPID IDENTIFICATION OF NEW DRUGS WILL FURTHER AFFECT THE CRIMINAL JUSTICE AND PUBLIC HEALTH COMMUNITIES. SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.
OpenAlex ID: W4417135052
FWCI: 0.253
Cites: 39
Cited by: 1
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