Year: 2025
Type: article
Abstract: One of the central challenges in oncology is understanding why tumours stop responding to therapy.Clinicians see this repeatedly: an initial response that gives way to relapse, often driven by the tumour's ability to adapt at the molecular level.These adaptations are not static.They unfold over hours, days, and weeks, and they vary across different regions of the same tumour.This means that the molecular programmes that enable a tumour to escape treatment are dynamic, spatially organised, and highly patient-specific.Yet the tools we use today, bulk sequencing, fixed-tissue analysis, and endpoint assays, capture only isolated moments in time.They fall short when clinicians need to know how a tumour changes during treatment, where resistance emerges within the tissue, and when a vulnerable state might be present.This gap calls for a new paradigm for tumour profiling: capturing molecular dynamics directly in living tissue, in both space and time (Figure 1).
DOI: 10.1002/ctm2.70547
Author: Ciro Chiappini
Institutions: King's College London, London Centre for Nanotechnology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,470
OpenAlex ID: W4417144347