Work

Visible-light-induced cascade radical sulfonation/annulation/isomerization reactions of propargyl chalcones with sodium sulfinates: Regioselective synthesis of sulfonyl 2H-chromene and 2H-quinoline derivatives

Year: 2025

Type: article

Abstract: A cascade approach has been developed for the one-pot three-step synthesis of sulfonyl-containing 2 H -chromenes and 2 H -quinoline derivatives from propargyl chalcones and sodium sulfinates. This protocol features only sodium sulfinates, as sulfonyl radical precursors can promote regioselective sulfonation/annulation reactions under visible-light photoredox conditions. Notably, the olefin isomerization smoothly proceeds, delivering only 2H -chromenes and 2H -quinoline products in the present protocol. The reaction shows a metal-free, mild condition reaction, broad functional group tolerance, and very good yields.

Source: Green Synthesis and Catalysis

DOI: 10.1016/j.gresc.2025.11.007

Authors: Wenli Sheng, Zhaocheng Shi, Huimin Li, Zhaohui Xu, Qingyan Liu, Junmin Chen

Institution: Jiangxi Normal University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: National Natural Science Foundation of China

Award: G6021052009