Work

Repeated visual perceptual micro-training enhances neural microplasticity in children with ametropic amblyopia: A clinical observation

Year: 2025

Type: article

Abstract: OBJECTIVE: The aim of this study was to evaluate the effects of repeated visual-perceptual micro training on neural microplasticity in children diagnosed with ametropic amblyopia, with a focus on changes in best-corrected visual acuity (BCVA), binocular visual function, and suppression. METHODS: A total of 35 children with ametropic amblyopia (mean age: 6.80 years) underwent intervention using a binocular visual perceptual neural plasticity training system. The training protocol consisted of 20 sessions, administered five times per week, each lasting 40 min. BCVA, suppression status, and stereopsis were assessed at baseline (T0), after five sessions (T1), after ten sessions (T2), and 4 weeks post-intervention (T3). RESULTS: Following ten training sessions, the mean BCVA improved from 0.72 to 0.88 in the right eye and from 0.70 to 0.90 in the left eye (p < 0.001). The prevalence of foveal suppression decreased from 51.43 % to 14.29 %, while the proportion of participants without suppression increased from 34.29 % to 57.14 % (p = 0.025). Significant improvements in fine stereopsis were observed at both 0.8 m and 1.5 m distances, with the proportion of individuals reaching grade 3-4 increasing to 82.86 % and 71.43 %, respectively (p < 0.01). The observed therapeutic effects remained stable throughout the follow-up period. CONCLUSION: Repeated visual perceptual micro-training demonstrated significant improvements in BCVA, binocular visual function, and suppression in children with ametropic amblyopia. These effects followed a cumulative enhancement pattern and remained stable during the 4-week post-training follow-up period, suggesting potential clinical applicability in amblyopia rehabilitation while highlighting the need for longer-term evaluation.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2025.105311

Authors: Fang-Fang Lan, Wu-Xiao Zhao, Lu Gan, Yan Luo, Zhi-Chao Li

Institution: The People's Hospital of Guangxi Zhuang Autonomous Region

Language: English

Topic: Ophthalmology and Visual Impairment Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Quality education

Open Access status: gold

Estimated APC paid: $2,610