Work

C–H (radio)fluorination of hydroxamides via strained and electronically tunable α-lactams enabled by N–O scission

Year: 2025

Type: article

Abstract: F-standards for imaging agent characterisation is efficiently realised under an analogous protocol, which was modified to selectively deliver α-lactams (aziridinones) with unprecedented resistance to decomposition. A fluorination mechanism involving NO scission, lactamisation, and strain-release-driven CN ionisation is proposed. These protocols provide a versatile platform for the radiosynthesis of fluoroamides with high PET production utility.

Source: Nuclear Medicine and Biology

DOI: 10.1016/j.nucmedbio.2025.109594

Authors: Siran Qian, Surendra Reddy Gundam, Carol Garcia, Shihong Li, Hsiaoju Lee, Jay S. Wright

Institution: University of Pennsylvania

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,740