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Palladium(0) and Juglone: a new alliance in the fight against ovarian cancer

Year: 2025

Type: article

Abstract: Four Juglone-based Pd(0) complexes with varied ligands were synthesized and characterized. They showed strong cytotoxicity and cancer selectivity. The most promising complex inhibited the PIN1 oncoprotein, as confirmed by Western Blot.

Source: Dalton Transactions

DOI: 10.1039/d5dt01792k

Authors: Giovanni Tonon, Anna Rafaniello, Matteo Mauceri, Nicola Demitri, Thomas Scattolin, Flavio Rizzolio, Fabiano Visentin

Institutions: Ca' Foscari University of Venice, Elettra-Sincrotrone Trieste S.C.p.A., University of Padua, Centro di Riferimento Oncologico

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Associazione Italiana per la Ricerca sul Cancro

Award: G8152518880

OpenAlex ID: W4417152802

FWCI:

Cites: 77

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