Work

Outcomes of pancreatoduodenectomy in underlying liver cirrhosis: a single institution experience and literature review

Year: 2025

Type: article

Abstract: INTRODUCTION: Pancreatoduodenectomy (PD) is a complex procedure associated with up to 20-30% morbidity and 1-2% mortality. In the present study, we aimed to evaluate the outcomes of PD in patients with cirrhotic liver and assessed predictors of perioperative morbidity and mortality. MATERIALS AND METHODS: This is a retrospective study from a prospectively maintained database. Amongst the patients who underwent PD between January 2013 till June 2024, only patients who had underlying cirrhotic liver were included in the study. RESULTS: A total of 24 patients were included. On binary logistic regression history of pancreatitis in the preoperative period (OD-25.8), stent block (OD-64.9), cholangitis (OD-273), and preoperative platelets less than 1.37(OD-40), preoperative INR more than 1.31(OD-40) and platelets count on POD1 less than 1.23 lakhs (OD-40) were associated with mortality. CONCLUSION: Patients with clinically significant portal hypertension with thrombocytopenia and a deranged coagulation profile are associated with a high risk of mortality.

Source: Langenbeck s Archives of Surgery

DOI: 10.1007/s00423-025-03912-4