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Fast-switching pH-responsive biomimetic ion channels with bidirectional gating control

Year: 2025

Type: article

Abstract: conformational changes, mirroring that of natural ASICs. Stopped-flow experiments further demonstrated that this biomimetic system exhibits millisecond-timescale gating kinetics under pH modulation, achieving response rates comparable to those of natural ion channels.

Source: Chemical Science

DOI: 10.1039/d5sc07123b

Authors: Wen Zhao, Linlin Shi, Juan Chen, Jingjing Ma, Qingqing Lv, Yonghui Sun, Nan Lv, Xiaoyu Chang, Pengyang Xin

Institutions: National Medical Products Administration, Henan Normal University, Zhengzhou University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Henan Normal University, National Natural Science Foundation of China, Natural Science Foundation of Henan Province, Henan Key Laboratory of Organic Functional Molecules and Drug Innovation, Central Plains Scholars and Scientists Studio Fund

Awards: G1922678991, G1989771813, G3274520935, G6463669824, G7832643479, G834955428, G8980788973, G938183802

OpenAlex ID: W4417153383

FWCI: 1.192

Cites: 90

Cited by: 4

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