Cervical/Anal HPV‐Cytology Concordance With Colposcopic‐Anoscopic Pathology: 984 Women Without HIV in China's Largest Lower Genital Tract Center
Year: 2025
Type: article
Study design: Observational Study
Abstract: The anatomical and immunological parallels between cervical and anal canals raise questions about shared HPV pathogenesis. This study evaluated the concordance of HPV/cytology between sites and their association with histopathology. We retrospectively analyzed 984 women who underwent concurrent cervical/anal cytology and HPV testing (Jan, 2019-Jun, 2024). Subgroups included 706 with colposcopy-histopatholgoy and 265 with HRA-histopathology. Consistency was assessed using chi square tests, Cramér's V, and diagnostic performance metrics. HPV-16 dominated both sites (cervix: 27.54%; anus: 21.44%). Cervical-anal cytology showed weak-moderate agreement (Cramér's V = 0.225, p < 0.001), while HPV genotyping demonstrated stronger concordance (V = 0.458, p < 0.001), especially for HPV-16/18 (60%, 180 anal positive in 300 cervical positive). Histopathology correlation was weak (Spearman's ρ = 0.261). Anal HPV predicted anal LSIL+ poorly (PPV = 43.7%, AUC = 0.55). Combined anal HPV/LCT screening improved sensitivity (89.2%) but reduced specificity (22.1%). While cervical and anal HPV infections are moderately associated, the considerable site-specific disparities in cytological and histopathological findings underscore the need for independent clinical assessment of each site.
Source: Journal of Medical Virology
DOI: 10.1002/jmv.70710
Authors: Qing Li, Yuankui Cao, Yi Yu, Yi Zhang, Limei Chen, Qing Cong
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4417154173