Work

Tramadol for treatment of neurogenic cough: a retrospective case series

Year: 2025

Type: article

Abstract: Objectives This study aimed to explore the efficacy of tramadol for neurogenic cough and describe the longitudinal treatment experience. Methods A retrospective case series of adults with chronic cough who were treated with tramadol for neurogenic cough. A complete response was defined as no pathologic coughing, and a partial response was defined as 50 per cent or greater reduction in severity or frequency. Results Sixty-nine patients were included: 38 per cent of patients reported a complete response with an additional 33 per cent reporting a partial response. The most common successful dosing regimen was 50 mg twice a day. Age, gender and body mass index did not impact treatment response. Patients with a history of laryngeal surgery were less likely to respond ( p = 0.04). Sedation (10 per cent) was the most common side effect. Fifty per cent of complete responders ( n = 13) were weaned off tramadol after a mean of 39 weeks of treatment. Conclusion Tramadol may be effective and is well tolerated in patients with neurogenic cough.

Source: The Journal of Laryngology & Otology

DOI: 10.1017/s0022215125103915

Authors: Benjamin Joseph Rubinstein, Sheela Saidha, John Todd Sinacori

Institutions: Eastern Virginia Medical School, Old Dominion University

Language: English

Topic: Respiratory and Cough-Related Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550