Epstein‑Barr virus + inflammatory follicular dendritic cell sarcoma with clonal immunoglobulin heavy chain gene rearrangement: A case report and literature review
Year: 2025
Type: article
Study design: Case Report
Abstract: Epstein-Barr virus + inflammatory follicular dendritic cell sarcoma (EBV + IFDCS) is a tumor with relatively inert biological behavior and low malignancy.Due to the lack of clinical features and non-specific imaging examinations, EBV + IFDCS is difficult to diagnose preoperatively.The histological morphology and immunophenotype of EBV + IFDCS are very broad, in which the presentation of EBV + IFDCS with marked granulomatous changes is rare and can be confused with other granulomatous diseases.The present study reported a case of EBV + IFDCS with marked granuloma formation.Notably, the present case report detected gene rearrangements using PCR-capillary electrophoresis and identified an amplification peak in the DH7-JH region of the immunoglobulin heavy chain, which has rarely been reported in previous cases, to the best of our knowledge.We hypothesized that this rearrangement may be associated with background B cells.
Source: Oncology Letters
Authors: Qian Ye, Juan Zhao, Jiao He, Weishan Zhang
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4417158757
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