Work

Targeted PGC-1α gene delivery by GV-assisted ultrasound cavitation for renal ischemia-reperfusion injury therapy

Year: 2025

Type: article

Abstract: evidence reveal that ultrasound-mediated gene transfection with Fuc-pPGC-1α-GVs could ameliorate renal IRI by rescuing the function of ECs, decreasing immune cell infiltration, and alleviating renal tubular injury. Mechanistically, overexpressed PGC-1α in injured renal ECs promotes mitophagy and inhibits ROS production by upregulating BNIP3, BNIP3L, and SOD2. This study provides a promising strategy for the early and efficient treatment of renal IRI.

Source: iScience

DOI: 10.1016/j.isci.2025.114374

Authors: Yuxian Kuai, Wen Xu, Xue Wang, Xiaodan Xu, Pintong Huang

Institutions: Second Affiliated Hospital of Zhejiang University, Zhejiang University

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240