Intestinal adaptations increase basolateral intestinal glucose uptake and glycolysis in a mouse model of cystic fibrosis
Year: 2025
Type: article
Abstract: We found transcriptional, protein level, and functional evidence of increased intestinal glucose uptake from circulation and increased glycolysis in a cystic fibrosis mouse model. These findings in the context of hyperplastic morphologic and histologic changes in the cystic fibrosis intestine are indicative of an adaptive response. Our work elucidates new mechanisms of intestinal disease in cystic fibrosis and identifies altered intestinal glucose uptake and glycolysis as potential markers of disease status and gastrointestinal cancer risk.
Institutions: Case Western Reserve University, Cleveland Clinic
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4417166758