Work

A human cardiomyocyte-based cellular model mimicking cardiac ischemia

Year: 2025

Type: article

Abstract: In this study, we developed a novel in vitro model of cardiac ischemia using cardiomyocytes derived from induced pluripotent stem cells. Cells were exposed to oxygen and nutrient deprivation, followed by proinflammatory cytokines to mimic postischemic inflammation. This approach reproduces key features of ischemic injury, including mitochondrial dysfunction, impaired contractility, and morphological changes. The model provides a valuable tool for studying cardiac pathophysiology and testing therapeutic strategies while reducing reliance on animal models.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00363.2025

Authors: Jean-Sébastien Vartanian-Grimaldi, Onnik Agbulut

Institutions: Sorbonne Université, Institut de Biologie Paris-Seine

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid