Work

Prognosis of central venous catheter-related Candida infection during hospitalization in conventional medical or surgical wards: A 13-year retrospective cohort study

Year: 2025

Type: article

Abstract: OBJECTIVES: While catheter-related Candida infections in intensive care settings are well-described, data from conventional medical or surgical wards remain limited. This study aims to identify the clinical characteristics and prognostic factors of catheter-related Candida infections in such settings. METHODS: We conducted a retrospective single-center cohort study from 2008 to 2022, including patients with confirmed catheter-related Candida infection. Diagnosis was based on a positive central blood culture, along with either a positive peripheral blood culture, local inflammatory signs, or radiological signs suggesting catheter-related candidemia. The main outcome was either transfer to the intensive care unit or death within 30 days. RESULTS: Following a univariate analysis, 15 (30 %) patients among a total of 50 had an unfavorable outcome: eight (16 %) were transferred to the intensive care unit, and seven (14 %) died within 30 days. Poor outcome was associated with age over 60 years, clinical severity, and positive mannan biomarkers. CONCLUSION: Catheter-related Candida infections in non-critical care settings are associated with significant morbidity and mortality. Fungal biomarkers may hold clinically relevant prognostic value, necessitating further investigations.

Source: Infectious Diseases Now

DOI: 10.1016/j.idnow.2025.105227

Authors: Aida Zaghdoudi, Arthur Hacquin, Stéphane Valot, Mathieu Blot, Lionel Piroth, Thibault Sixt