An adenovirus-vectored recombinant vaccine confers passive immunity protection from swine acute diarrhea syndrome coronavirus challenge in neonatal mice
Year: 2025
Type: article
Abstract: Swine acute diarrhea syndrome coronavirus (SADS-CoV), an emerging bat-origin Alphacoronavirus with demonstrated zoonotic potential, poses a significant threat to swine health and has considerable economic implications. Currently, no licensed vaccines are available. We constructed a replication-deficient human adenovirus type 5 (Ad5) vectored vaccine candidate, rAd5-SADS-S, which expresses the SADS-CoV spike (S) glycoprotein. The rAd5-SADS-S vaccine elicited robust SADS-CoV-specific humoral immunity and potent cellular responses in both mice and pigs. Notably, rAd5-SADS-S conferred passive protection to neonatal mice against lethal SADS-CoV challenge. These findings establish a preclinical foundation for the development of SADS-CoV vaccines.
Source: Virologica Sinica
Authors: Yu Zhang, Yueyue Duan, Xueliang Zhu, Lei Shi, Juan Zhang, Wenquan Mao, Luyao Li, Cong Yuan, Maowen Sun, Haixue Zheng, Qi Wang
Language: English
Subfield: Animal Science and Zoology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $1,500
Awards: G3073424556, G6859813022, G8048042174
OpenAlex ID: W4417178221