Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019–2024
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The REIDAC (Spanish Registry for Research in Contact Dermatitis) conducts nationwide epidemiological surveillance of contact dermatitis in Spain. Anogenital involvement within REIDAC has not been previously studied. OBJECTIVES: To describe the most common diagnoses and update relevant allergens in patients with anogenital lesions referred for patch testing. METHODS: We analysed patients who underwent patch testing within REIDAC from 2019 to 2024. Patients were classified into three groups: (G1) exclusively anogenital lesions, (G2) no anogenital involvement and (G3) both anogenital and non-anogenital lesions. Sensitisation and relevance were assessed. RESULTS: Among 18 291 patients, 116 (0.6%) had exclusively anogenital lesions, 17 576 (96.1%) had no anogenital involvement and 599 (3.3%) had both. G1 patients were more likely to have at least one positive reaction (91.4%), a current relevant reaction (53.4%, diagnosed with allergic contact dermatitis, ACD) and to be polysensitised compared to other groups (p < 0.001). 14.5% of anogenital ACD identified cases were not identified by the Spanish baseline series. Fragrances, preservatives, topical anaesthetics and steroids were the leading relevant allergens. Benzisothiazolinone, sodium metabisulfite and propolis emerged as new sensitisers. CONCLUSION: ACD was highly prevalent among patients with anogenital lesions referred for patch testing. The threshold for patch testing in these patients may need reconsideration.
Source: Contact Dermatitis
DOI: 10.1111/cod.70048
Authors: Mercè Grau‐Pérez, Pedro Mercader‐García, Ana María Giménez‐Arnau, Tatiana Sanz‐Sánchez, Violeta Zaragoza Ninet, Susana Córdoba Guijarro, Francisco Javier Miquel Miquel, Juan Francisco Silvestre Salvador, Ricardo González‐Pérez, Inmaculada Ruíz González, Esther Serra Baldrich, José Manuel Carrascosa, Francisco Javier Ortiz de Frutos, Mercedes Rodríguez Serna, María Elena Gatica Ortega, Carmen Paredes Suárez, Francisco José Navarro Triviño, Pablo Chicharro, Marta Andreu, Araceli Sánchez Gilo, José Juan Pereyra Rodríguez, María Antonia Pastor Nieto, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Enrique Gómez de la Fuente, Marta Elosua‐González, Mónica Munera‐Campos, Fátima Tous Romero, Miguel Ángel Descalzo, Leopoldo Borrego
Institutions: Hospital Universitario Puerta de Hierro Majadahonda, Hospital General Universitario Morales Meseguer, Universitat Pompeu Fabra, Hospital del Mar Research Institute, Hospital Universitario Infanta Sofía, Universidad Europea de Madrid, Hospital General Universitario De Valencia, Hospital Universitario de Fuenlabrada, Hospital Universitari Arnau de Vilanova, Hospital Arnau de Vilanova, Hospital General Universitario de Alicante Doctor Balmis, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), University of the Basque Country, Hospital Universitario Araba, Complejo Asistencial Universitario de León, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Hospital Universitario 12 De Octubre, Hospital Universitari i Politècnic La Fe, Complejo Hospitalario Universitario de Toledo, Hospital Universitario de Toledo, Complejo Hospitalario Universitario de Santiago, Hospital Universitario de La Princesa, Hospital Universitario Fundación Alcorcón, Hospital Universitario Rey Juan Carlos, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Hospital Universitario Fundación Jiménez Díaz, Hospital Universitari Sagrat Cor, Hospital Universitario Virgen de la Arrixaca, Hospital Universitario Ramón y Cajal, Universidad de Las Palmas de Gran Canaria, Hospital Universitario Insular de Gran Canaria
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,060
OpenAlex ID: W4417178765