Work

N6-methyladenosine (m6A) of LINC01315 promotes hepatocellular carcinoma progression by activating β-Catentin/WNT pathway

Year: 2025

Type: article

Abstract: Hepatocellular carcinoma (HCC) is a globally prevalent and aggressive form of hepatic cancer. Both N 6 -methyladenosine (m 6 A) and long non-coding RNAs (lncRNAs) modification are identified as key mediators of HCC progression. However, comprehensive genome-wide studies and functional annotations of m 6 A-modified lncRNAs in HCC are still limited. In this study, LINC01315 demonstrated a significant increase in HCC and was closely associated with patient survival. METTL3 was shown to increase LINC01315 expression by acting as its m 6 A methyltransferase, while YTHDF1 served as the respective m 6 A reader. LINC01315 promoted the growth and metastatic ability of HCC. LINC01315 acts as a competing endogenous RNA (ceRNA) for miR-185-5p, which elevated β-catenin levels and activated the WNT signaling cascade in HCC cells. These findings highlight that METTL3 -driven LINC01315 accelerates HCC cell propagation, invasion, and migration via the LINC01315/miR-185-5p/β-catenin/WNT signaling axis. LINC01315 could serve as a potent prognostic marker and treatment option in HCC.

Source: Scientific Reports

DOI: 10.1038/s41598-025-32019-5

Authors: Ming-xuan Xing, Bao-zhuang Sun, Teng-yue Zou, Ren-zheng Liu, Guang-jin Li, Wen-xiao Li

Institutions: Shandong University, Weihai Municipal Hospital, Binzhou Medical University

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690