Year: 2025
Type: article
Study design: Systematic Review
Abstract: Neurodegenerative diseases represent a major public health challenge due to their high prevalence and poor prognosis. Identifying biomarkers to stratify individuals by their risk of developing these diseases may help to define new personalized prevention interventions. The objective of this study was to conduct a scoping review of biomarkers for primary and secondary personalized prevention of neurodegenerative diseases. The search targeted biomarkers in adults or high-risk subpopulations in clinical or public health settings for Alzheimer's disease, vascular dementia, Lewy body disease, frontotemporal dementia, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis. Ultimately, 286 papers were included in the review and the interactive gap map. There is a strong focus on Alzheimer's disease, and most papers included -omics-based biomarkers and/or used artificial intelligence. Genetics/genomics are at the forefront of current scientific research, although there is a notable gap in studying gene-environment interactions, and studies in clinical settings are still scarce. HIGHLIGHTS: Research indicates a strong focus on Alzheimer´s disease and limited research in other diseases. Genetics and genomics are at the forefront of current scientific research. We found biomarkers for predicting progression in mild cognitive decline. There is a notable gap in studying gene-environment interactions. Studies investigating biomarkers in a clinical context are still scarce.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.70980
Authors: Cristina Barahona‐López, Elena Plans‐Beriso, Paul Diez‐Echave, Orlando Hernández, Nerea Fernández de Larrea, Oana Craciun, Ester García‐Ovejero, Dafina Petrova, Nicolás Francisco Fernández‐Martínez, Estíbaliz Arruabarrena‐Blanco, Chantal Babb‐de‐Villiers, Heather Turner, Ramon Cierco Jimenez, Chaitanya Erady, Hayley Wilson, Pablo Fernández‐Navarro, Esther García García‐Esquinas, Isla Kuhn, Pascual Sánchez, Fernando Rodríguez‐Artalejo, María José Sánchez, Víctor Moreno, Laura Blackburn, Marina Pollán, Mark Kroese, Beatriz Perez‐Gomez
Institutions: Instituto de Salud Carlos III, Centro Nacional de Epidemiología, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario Virgen de las Nieves, Andalusian School of Public Health, University of Cambridge, PHG Foundation, Centre international de recherche sur le cancer, Madrid Institute for Advanced Studies, IMDEA Food, Universidad Autónoma de Madrid, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
OpenAlex ID: W4417180926