Work

Evaluation of tonsillectomy in the treatment of SAPHO syndrome: past evidence and future directions

Year: 2025

Type: article

Abstract: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare aseptic inflammatory clinical syndrome characterized by widespread skin lesions and bone-joint lesions. The underlying mechanisms remain unclear, making it difficult to treat. Currently, drug-based symptomatic treatment is the main approach, but symptoms often recur or worsen when medications are reduced or discontinued. Recently, there have been increasing reports of the significant therapeutic effects of tonsillectomy in treating SAPHO syndrome. This paper reviews the past evidence on the use of tonsillectomy for SAPHO syndrome by searching PubMed, Google Scholar, Web of Science, Embase, Scopus, CNKI, and Wanfang databases using the keywords "SAPHO syndrome and tonsillectomy." It also discusses the potential mechanisms of tonsillectomy in treating SAPHO syndrome, aiming to provide new treatment methods for SAPHO syndrome.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1695572

Authors: Wen-Yuan Gan, Ben-Hong Ren, Qing-Ping Zhang, Yi Wang

Institutions: Qinghai University Affiliated Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital

Language: English

Topic: Osteomyelitis and Bone Disorders Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801