Ultrasonic-assisted, additive-free Pd-catalyzed Suzuki–Miyaura cross-coupling enabled synthesis of novel arylated benzofuran-triazole hybrids
Year: 2025
Type: article
Abstract: An additive-free and ultrasound-assisted approach has been established for the Suzuki–Miyaura cross-coupling reaction between substituted boronic acid and benzofuran-endowed aryl halides by employing a catalytic amount of Pd(PPh 3 ) 4 . The resulting substituted biaryls were then employed as efficient starting materials to furnish a novel library of arylated benzofuran-triazole hybrids 13(a–i) . The method offers a facile, efficient, and less time-consuming approach under non-inert conditions to synthesize the targeted derivatives in a good to excellent yield range of 70%–92%.
Source: Frontiers in Chemistry
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: Uniwersytet Medyczny w Lublinie
Award: G102805623
OpenAlex ID: W4417182248