“Biomarkers of immune hyperactivation and inflammation are elevated in pregnancies complicated by fetal Trisomy-21”
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To compare interferon-linked/inflammatory biomarkers (neopterin, indoleamine-2,3-dioxygenase [IDO], and YKL-40) in maternal serum and amniotic fluid between Trisomy-21 and chromosomally normal pregnancies. METHODS: This prospective case-control study included pregnancies diagnosed with Trisomy-21 and chromosomally normal pregnancies as controls. Neopterin, IDO, and YKL-40 levels in maternal serum and amniotic fluid samples were measured using ELISA. RESULTS: < 0.05), respectively, in the Trisomy-21 group. Maternal serum IDO showed a trend toward increase in Trisomy-21 pregnancies, while amniotic fluid levels did not differ between groups. All measurements were above assay detection limits. CONCLUSION: Trisomy-21 pregnancies showed elevated AF neopterin and elevated MS YKL-40, while IDO was not significantly different. This pattern is compatible with differences in interferon-linked inflammatory/vascular pathways in Trisomy-21 preg-nancies, but does not establish a mechanism. Further studies are needed to validate these findings.
Institutions: Gaziantep Şehir Hastanesi, Inonu University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4417183759