Photoredox/Nickel Dual-Catalyzed Asymmetric C-Alkylation of Nitroalkanes with α-Bromoketones
Year: 2025
Type: article
Abstract: A stereoselective method for alkylating nitroalkanes with α-bromoketones using nickel/photoredox dual catalysis is described. The mild and functional-group-tolerant conditions allow the formation of complex and highly enantioenriched β-nitroketone products that hold promising utility as precursors for the formation of biologically relevant compounds.
Source: Organic Letters
Institution: University of Delaware
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: G1023404490, G1210435683, G1382022822, G1703205069, Discovery of Chemical Probes and Therapeutic Leads, Phase II, G4584425727, G5233324464, G545157245, G5776458082, G5900546874, High Performance Digital NMR Spectrometer, G8414554082, Molecular Design of Advanced Biomaterials, MRI: Acquisition of a High Resolution Mass Spectrometer for Small Molecule Analysis, G9000042617, G9000096486, Q-Exactive Orbitrap LC-MC/MS System
OpenAlex ID: W4417184170