Work

Successful Alternative Administration of Sonidegib in a Patient with Gorlin-Goltz Syndrome and Dysphagia: A Case Report

Year: 2025

Type: article

Abstract: Introduction: Activation of the Hedgehog (HH) pathway is a key factor in the development of basal cell carcinoma. Case Presentation: Approved HH pathway inhibitors, like vismodegib and sonidegib, are supplied in capsule form. Patients who suffer from dysphagia may have problems swallowing these medications. Conclusion: This case report describes the successful use of an alternative administration of sonidegib in a patient with Gorlin-Goltz syndrome and dysphagia.

Source: Case Reports in Dermatology

DOI: 10.1159/000546383

Authors: Armin Bender, Lisa Krönig

Institution: Universitätsklinikum Gießen und Marburg

Language: English

Topic: Hedgehog Signaling Pathway Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030