Work

Severe Hypocalcemia as an Unexpected Trigger for Psoriasis Exacerbation in Chronic Hypoparathyroidism: A Case Report

Year: 2025

Type: article

Abstract: Hypoparathyroidism-induced hypocalcemia represents a rare cause for psoriasis exacerbation through various mechanisms including disruption of calcium-dependent keratinocyte differentiation and proliferation pathways. Epidermal barrier function and normal keratinization processes are normally maintained by normal calcium levels, where its deficiency can end in abnormal inflammatory processes and impaired skin homeostasis. We present a 52-year-old Egyptian male with chronic post-surgical hypoparathyroidism who developed severe psoriatic plaques during periods of profound hypocalcemia (7.2 mg/dL). Marked improvement of skin lesions as well as normalization of calcium levels were achieved through psoriasis therapy along with aggressive calcium, demonstrating the therapeutic importance of addressing underlying metabolic abnormalities in dermatological conditions, especially psoriasis.

Source: Clinical Medicine Insights Case Reports

DOI: 10.1177/11795476251404256

Authors: Wael Hashem, Ziad W. Elmezayen, Zeina Hashem, Sohaib AlAdam

Institutions: An-Najah National University, Kafrelsheikh University

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,650