Supplementary Figure 1 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
Year: 2025
Type: supplementary-materials
Abstract: Supplementary Figure S1: p53 hotspot mutations (A) Crystal structure of p53 bound to DNA PDB 1TUP with structural and DNA-contact mutations highlighted. (B) Frequency of hotspot mutations out of total p53 alterations based upon data generated by the TCGA Research Network: https://www.cancer.gov/tcga. (C) The urea-denaturation free energy values from hotspot mutations and stabilizing mutations plotted from previous studies (7). (D) SDS-PAGE of recombinant protein used in study stained with Coomassie blue.
Authors: Keelan Z. Guiley, Kevan M. Shokat
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4417194347