Supplementary Figure 4 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
Year: 2025
Type: supplementary-materials
Abstract: Supplementary Figure S4: Ligand electron density maps (A) 1σ 2Fo-Fc electron density map and 1.5σ Fo-Fc simulated annealing omit density map for KG3. (B) 1σ 2Fo-Fc electron density map and 1.5σ Fo-Fc simulated annealing omit density map for KG6. (C) 1σ 2Fo-Fc electron density map and 1.5σ Fo-Fc simulated annealing omit density map for KG10. (D) 1σ 2Fo-Fc electron density map and 1.5σ Fo-Fc simulated annealing omit density map for KG13. (E) Allosteric stabilization by KG6. D228 makes intramolecular contacts with V147 amine rather through a small molecule directly.
Authors: Keelan Z. Guiley, Kevan M. Shokat
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4417194662