Figure 2 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
Year: 2025
Type: other
Abstract: A methacrylic indole compound induced a novel p53 conformational state. A, Chemical structures of methacrylic indole compound series. B, 1 μmol/L p53 Y220C-CL was incubated with 10 μmol/L indole series at 4°C for 24 hours. Adduct formation was analyzed by LC/MS. C, Crystal structure of p53 Y220C-CL bound to KG6 in a novel conformational state at 1.6 Å resolution. D, Crystal structure of p53 Y220C-CL bound to KG10 at 2.0 Å resolution.
Authors: Keelan Z. Guiley, Kevan M. Shokat
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4417194675