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Adult Acute Myeloid Leukaemia With DDX3X::MLLT10 : A Rare Entity With Significant Unmet Clinical Needs

Year: 2025

Type: article

Abstract: ¸ which arises from t(X;10)(p11.4;p12.31), is infrequently observed in adult acute myeloid leukaemia (AML). The clinical and pathological characteristics are also not well characterised, detailed in only two cases published to date. This third case reports the fusion gene in a 27-year-old female with acute myelomonocytic leukaemia (AMML) with refractoriness to multiple lines of chemotherapy. Collectively, these cases highlight the genomic heterogeneity of this rare entity, as well as significant unmet clinical needs due to the poor prognosis and chemoresistance observed. These findings may inform future iterations of AML classification and prognostication in adults.

Source: eJHaem

DOI: 10.1002/jha2.70181

Authors: Jun Yen Ng, Arun SR, Maansi Joshi, Dipti Talaulikar

Institutions: Australian National University, Canberra Hospital

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,860