Work

Percutaneous Closure of Residual Shunt After Patent Foramen Ovale Closure With a Biodegradable Occluder

Year: 2025

Type: article

Abstract: BACKGROUND: Residual right-to-left shunt (RLS) after patent foramen ovale (PFO) closure may lead to recurrent stroke or migraine. Conventional metallic occluders often entail shortcomings, including suboptimal conformability and permanent metal implantation. Biodegradable occluders offer potential advantages through enhanced compatibility and gradual resorption. CASE SUMMARY: A 52-year-old woman who developed recurrent cerebral infarction and migraine 20 months after PFO closure was diagnosed with a residual RLS, which was subsequently successfully treated using a biodegradable PFO occluder. DISCUSSION: We herein report a successful case of residual RLS management using a biodegradable PFO occluder, offering a novel therapeutic strategy for the treatment of residual shunts after PFO closure. NOVELTY: To our knowledge, this is the first reported case demonstrating the successful clinical application of a biodegradable PFO occluder for the transcatheter closure of residual shunt after initial PFO closure. TAKE-HOME MESSAGE: This case highlights the feasibility and efficacy of a biodegradable device for managing residual shunt, providing a novel therapeutic option in selected patients.

Source: JACC Case Reports

DOI: 10.1016/j.jaccas.2025.105901

Authors: Dong Luo, Luxi Guan, Hongxiao Li, Jianhua Lv, Haibo Hu, Xiangbin Pan

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Fu Wai Hospital, Hebei General Hospital

Language: English

Topic: Cardiovascular and Diving-Related Complications

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $850