Work

HTRS2025.P2.72 Children with congenital heart disease have an increased risk of single lineage autoimmune cytopenias and Evans syndrome: evidence for loss of thymic function over time

Year: 2025

Type: article

Abstract: Background: Thrombocytopenia and anemia are common in the setting of congenital cardiac disease (CHD). Depending on the lesion, 20-48% of patients with cyanotic congenital heart disease may have some degree of thrombocytopenia that inversely correlates with hemoglobin postulated to be due to the degree of hypoxemia and cyanosis. Because the thrombocytopenia may be associated with degree of right-to-left shunting, decreases in platelet counts may also portend worsening prognosis. We had noted a cohort of patients with congenital heart disease with severe thrombocytopenia, or hemolytic anemia, or both that appeared to be immune mediated rather than related specifically to underlying cardiac physiology.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2025.103092

Authors: Michele P. Lambert, Paul Gallo, Linah Omer

Institution: Children's Hospital of Philadelphia

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250