Work

Comparing COVID-19 Variants in Children Hospitalized for Concern of Tracheostomy-associated Infection: A Multicenter Prospective Cohort Study

Year: 2025

Type: article

Abstract: In this ancillary study of a larger, prospective cohort study, we sought to compare presentation and outcomes of COVID-19 infections by variant (alpha, delta, and omicron) in 103 children with tracheostomy (108 admissions) hospitalized for concern of bacterial tracheostomy-associated infection. Dexamethasone use was significantly higher with delta compared to alpha (78% vs. 40%; OR, 5.5; P = 0.04). Increased oxygen (76%-89%) and ventilatory support during hospitalization (35-67%) were noted across all variants. Death occurred in 3%-6% of patients.

Source: The Pediatric Infectious Disease Journal

DOI: 10.1097/inf.0000000000005080

Authors: Ilana Moffet, Naoko Kono, Margaret Rush, Christopher J. Russell, Andrea Hahn

Institutions: George Washington University, University of Southern California, Children's National, Stanford Medicine, Stanford University

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, Agency for Healthcare Research and Quality, National Center for Advancing Translational Sciences