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Impact of chromosomal polymorphisms on pregnancy outcomes after in vitro fertilization or intracytoplasmic sperm injection: A systematic review and meta-analysis

Year: 2025
Type: review
Abstract: Objective: Chromosomal polymorphisms (CPs), subtle variations in chromosome structure, have been previously reported in individuals with infertility, particularly among men. This systematic review and meta-analysis aim to analyze associations between CPs and pregnancy outcomes, focusing on spontaneous abortion rates. Methodology: fertilization (IVF) or intracytoplasmic sperm injection (ICSI)]. We applied the inverse variance method for pooled risk ratios (RR) with 95% confidence intervals (CIs). Results: From an initial 4271 articles, 16 studies met the inclusion criteria. The analysis evaluated CPs in relation to reproductive outcomes, including abortion rates (AR), fertilization rates (FR), cleavage rates (CR), clinical pregnancy rates (CPR), and good-quality embryo rates (GQER). No significant associations were observed between CPs and AR across men, women, or couples, though high heterogeneity suggested variability in study populations. CPs were associated with a modest reduction (7%) in FR (RR 0.93, 95% CI 0.88-0.97, I2 = 67.8; P-value = 0.04), and GQER (RR 0.93, 95% CI 0.89-0.96, I2 = 17.4; P-value = 0.30), and a small but statistically significant reduction CRs (RR 0.98, 95% CI 0.97-0.99, I2 = 0.0; P-value = 0.48). Conclusions: The study highlights the influence of CPs on certain fertilization and pregnancy outcomes, particularly GQER, FR and CR, while their impact on miscarriage and clinical pregnancy outcomes remains inconclusive. Further large-scale studies are necessary to investigate further associations.
DOI: 10.12669/pjms.41.12.13037
Authors: Liping Shen, Qiong Sun, Liwen Shen, Yurong Zhu, Yiwei Sun
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $400
OpenAlex ID: W4417221556
FWCI: 0.252
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Cited by: 1
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