Association Between Prophylactic Anti‐Seizure Medication and Early Post‐Traumatic Seizures: An International Observational Multicenter Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: ABSTRACT Evidence for the use of prophylactic anti‐seizure medication (ASM) in traumatic brain injury (TBI) in reducing the occurrence of early post‐traumatic seizure (EPTS) remains equivocal. This study aimed to analyze the prevalence of EPTS in children with TBI, compare clinical characteristics of those with and without EPTS, and explore the association between prophylactic ASM and EPTS. We performed an observational study among 28 pediatric intensive care units in 15 countries from January 2014 to October 2022. The rate of EPTS was compared between individuals prescribed prophylactic ASM and those who were not. Logistic regression was used to examine the association between ASM and EPTS. Among 697 children with TBI, 161 (23.1%) developed EPTS and 280 (40.2%) received prophylactic ASM treatment. Use of prophylactic ASM was associated with a lower likelihood of developing EPTS (27/280 (9.6%) vs. 134/417 (32.1%), p < 0.001). The most frequently used prophylactic ASMs were phenytoin, levetiracetam, and phenobarbital. Age ≤ 4 years and GCS ≤ 8 were associated with increased odds of developing EPTS (aOR 2.29, 95% CI 1.54–3.40, p < 0.001 and aOR 1.80, 95% CI 1.18–2.74, p = 0.01). Our data provide evidence supporting the potential protective role of prophylactic ASM against EPTS.
Source: MedComm
DOI: 10.1002/mco2.70524
Authors: Jian Ji, Juan D. Roa G, Shu‐Ling Chong, Quan Wang, Chin Seng Gan, Jane P. W. Ng, Thelma Elvira Teran Miranda, Freddy Israel Pantoja Chamorro, Lawrence Chi Ngong Chan, Qalab Abbas, Jacqueline S. M. Ong, Ivan J. Ardila, Yasser M. Kazzaz, Jesús A. Domínguez‐Rojas, Hiroshi Kurosawa, Susana Beatriz Reyes Domínguez, Natalia Elizabeth Gómez Arriola, Natalia Zita Watzlawik, Adriana Yock‐Corrales, Rubén Eduardo Lasso Palomino, Gabriela Aparicio, Paula Caporal, Rosa Elena de la Torre Gómez, Chunfeng Liu, Rujipat Samransamruajkit, Nattachai Anantasit, Deborah M. Turina, Marisol Fonseca Flores, Pei‐Chuen Lee, Francisco J. Pilar‐Orive, Hongxing Dang, Yek Kee Chor, Meixiu Ming, Juan C. Jaramillo‐Bustamante, Sebastián González‐Dambrauskas, Jan Hau Lee, Suyun Qian
Institutions: Capital Medical University, Beijing Children’s Hospital, Universidad El Bosque, SingHealth, SingHealth Duke-NUS Academic Medical Centre, KK Women's and Children's Hospital, Duke-NUS Medical School, University Malaya Medical Centre, University of Malaya, Chinese University of Hong Kong, Prince of Wales Hospital, Aga Khan University, Aga Khan University Hospital, National University of Singapore, Khoo Teck Puat Hospital, National University Hospital, National University Health System, King Abdullah International Medical Research Center, Kobe Children's Hospital, Hospital Universitario Virgen de la Arrixaca, Garrahan Hospital, Costa Rican Department of Social Security, Fundación Valle del Lili, Hospital de Niños Superiora Sor María Ludovica, Hospital Civil de Guadalajara, Sheng Jing Hospital, China Medical University, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Ramathibodi Hospital, Hospital General de Niños Ricardo Gutierrez, Mexican Social Security Institute, Hospital de Cruces, Children's Hospital of Chongqing Medical University, Chongqing Medical University, Sarawak General Hospital, Children's Hospital of Fudan University, Universidad de la República de Uruguay, Centro Hospitalario Pereira Rossell
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,500
Awards: G5536770020, G702409270
OpenAlex ID: W4417222236