Harnessing Oxidized Alginate Microgels for Rapid and Self‐Assembling Dental Tissue Organogenesis In Vitro and In Vivo
Year: 2025
Type: article
Abstract: Dental Tissue Organogenesis In article number 2500053, Zhaoming Wu, Sang Jin Lee, and co-workers investigate the use of modified fully biodegradable oxidized alginate microgels loaded with high-density dental cells to induce self-dental tissue organogenesis. Utilizing tooth-derived stem cells or embryonic cells, the system promotes self-tissue assembly in vitro, while in vivo validation demonstrates epithelial mesenchymal interactions and strong tissue integration with host tissue. This approach successfully facilitates robust 3D vascularized tissue formation and osteogenesis, highlighting significant potential for advancing craniofacial reconstruction.
Source: Small Science
DOI: 10.1002/smsc.70156
Authors: Chao Liang, Shuxuan Wu, Ziqi Huang, Zhenzhen Wu, Zhenzhen Wu, Siyuan Chen, Feiming Li, Karrie Mei‐Yee Kiang, Gilberto Ka‐Kit Leung, Indong Jun, Hwan D. Kim, Ann‐Na Cho, Hee Jung Lee, Honghyun Park, Yiu Yan Leung, Seong Jun Kim, Seil Sohn, Haram Nah, Jae Seo Lee, Il Keun Kwon, Dong‐Nyoung Heo, Sang‐woo Lee, Sang‐woo Lee, Zhaoming Wu, Zhaoming Wu, Sang Jin Lee, Sang Jin Lee
Institutions: University of Hong Kong, KIST Europe, Seoul National University of Science and Technology, The University of Sydney, Korea Institute of Materials Science, CHA University Bundang Medical Center, CHA University, Kyung Hee University, Kyung Hee University Dental Hospital, Seoul National University
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,350
OpenAlex ID: W4417226722