Work

Cold argon plasmas for non-enzymatic digestion of macromolecules

Year: 2025

Type: article

Abstract: We have developed surface treatment techniques utilising radiofrequency current cold argon plasmas (RF-CAP) for non-enzymatic digestion of macromolecules, exemplified here with peptides and proteins of varying sizes. These plasmas are able to rapidly digest condensed-phase macromolecules with minimal sample preparation, producing predictable fragments visible by LC-MS analysis.

Source: Chemical Communications

DOI: 10.1039/d5cc06333g

Authors: Daniel McGill, Daniel Simon, Siva Ramadurai, Felicia Green, Zoltan Takats

Institutions: Rutherford Appleton Laboratory, Rosalind Franklin Institute, Imperial College London, University of Regensburg

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: UK Research and Innovation, Engineering and Physical Sciences Research Council

OpenAlex ID: W4417230697

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Cites: 17

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