Work

Treatment of Dapsone-Induced Methemoglobinemia in a Transplant Recipient With Isosulfan Blue Allergy

Year: 2025

Type: article

Abstract: ABSTRACT Dapsone is often used for Pneumocystis jirovecii pneumonia prophylaxis in post-transplant patients when sulfamethoxazole/trimethoprim is not tolerated. Methemoglobinemia (MetHb) is a known side effect of dapsone, frequently treated with methylene blue. We describe unexplained hypoxemia in a post-transplant patient on dapsone, highlighting the need for a high index of suspicion to recognize and manage this disorder. In this case, cimetidine was used to successfully treat MetHb when methylene blue was unsafe due to an isosulfan blue allergy. This suggests cimetidine may be a safe, effective alternative for acute symptomatic dapsone-induced MetHb in high-risk patients.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001930

Authors: Joy Zhao, Caroline Conlon, Madison Force, Jamie Schulte, Kiran Goli, Dina Halegoua-De Marzio

Institutions: Thomas Jefferson University, Thomas Jefferson University Hospital

Language: English

Topic: Methemoglobinemia and Tumor Lysis Syndrome

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4417236262

FWCI: 0.608

Cites: 15

Cited by: 1

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