Work

Novel Furo[3,2‐b]Pyrrole Thiocarbohydrazone as a Multi‐Ion Responsive Colorimetric Chemosensor for Copper, Mercury, Nickel, and Phosphate Ions

Year: 2025

Type: article

Abstract: ABSTRACT Two novel compounds, furo[3,2‐b]pyrrole carbohydrazone ( F 1 ) and thiocarbohydrazone ( F 2 ), were designed, synthesized, and evaluated as colorimetric sensors for ion detection. Their structures were thoroughly characterized using 1 H‐NMR, 13 C‐NMR, and ESI‐mass spectroscopy (MS). Although F 1 showed no significant response, F 2 exhibited multi‐ion responsiveness for Cu 2+ , Hg 2+ , Ni 2+ , and PO 4 3− in a dimethyl sulfoxide (DMSO):phosphate‐buffered saline (PBS) medium. The recognition mechanism, binding stoichiometry, and detection limits were examined through ultraviolet (UV)–Vis spectroscopic titrations and theoretical DFT studies. The binding mode was 1:2 ( F 2 :ion), with detection limits of 3.5, 4.2, 3.2, and 6.9 µM for Hg 2+ , Ni 2+ , Cu 2+ , and PO 4 3− , respectively. These experimental results were consistent with our theoretical DFT calculations. This work could be considered the first report of a simple, organic colorimetric sensor for the naked‐eye detection of PO 4 3− . This probe's excellent multi‐ion responsiveness and practical applicability, demonstrated through paper strip tests and water sample analysis, position it as a promising tool for real‐world applications.

Source: ChemistrySelect

DOI: 10.1002/slct.202504315

Authors: Slieman Milaneh, Fuyang Dong, Chun Zhang, Wen‐Long Wang

Institutions: Jiangnan University, Higher Institute for Applied Sciences and Technology

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities

Awards: G4614633758, G6442106538