Work

Pan-immune-inflammation value is associated with all-cause and cause-specific mortality among individuals with cancer survivors: a population-based longitudinal cohort study

Year: 2025

Type: article

Abstract: BACKGROUND: This study examines whether the pan-immune inflammation value (PIV) is linked to all-cause, cardiovascular disease (CVD), and cancer-specific mortality in individuals with a history of cancer. Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed to further explore the potential mediating influence of estimated glomerular filtration rate (eGFR) on the PIV-mortality relationship. METHODS: We included 3773 cancer survivors from NHANES (2003-2018). Mortality follow-up was conducted via linkage to the National Death Index. Associations between PIV and mortality outcomes were assessed using restricted cubic spline curves and weighted multivariable Cox regression. Mediation analysis evaluated whether eGFR partly explains the effect of PIV on mortality. RESULTS: Over a median follow-up of 84.75 months, 1137 deaths occurred (all-cause: 30.14 %; CVD: 8.32 %; cancer: 9.09 %). Using an optimal cutoff of 344.63, participants were classified into low (n = 2335) and high PIV (n = 1438) groups. In fully adjusted models, high PIV was associated with increased risks of all-cause mortality (HR 1.36, 95 % CI 1.18-1.56) and cancer-related mortality (HR 1.42, 95 % CI 1.10-1.82). eGFR mediated 9.10 % of the association between PIV and all-cause mortality and 11.47 % for CVD mortality, but not significantly for cancer mortality. CONCLUSION: Elevated PIV independently predicts higher all-cause and cancer-specific mortality in cancer survivors. The findings suggest that PIV may serve as a practical prognostic marker, with renal function partially accounting for its link to mortality.

Source: Cancer Treatment and Research Communications

DOI: 10.1016/j.ctarc.2025.101070

Authors: Juhua Dai, Xinping Sun, Bozhi Lin, Yujing Sun, Liyuan Chen

Institution: Peking University International Hospital

Language: English

Topic: Inflammatory Biomarkers in Disease Prognosis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,740