Plectin associates with focal adhesions and contributes to cytoskeletal organization and mechanical properties of astrocytes
Year: 2025
Type: article
Abstract: Plectin contributes to FA dynamics in astrocytes and exhibits spatial polarization within individual FAs as revealed by superresolution microscopy (SIM and STED). Atomic force microscopy demonstrated that plectin deficiency alters cell viscoelasticity, unveiling the role of plectin in the mechanical properties of astrocytes. Plectin expression, along with the FA protein vinculin, is upregulated in astrocytes cultured under serum-containing conditions-an in vitro model of reactive astrocytes-compared with serum-free, native-like conditions.
Institutions: University of Ljubljana, Celica (Slovenia), Masaryk University, International Clinical Research Center, St. Anne's University Hospital Brno, St. Anne's University Hospital Brno, Consejo Superior de Investigaciones Científicas, Centro de Investigaciones Biológicas Margarita Salas, University of Vienna, Max Perutz Labs
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
Awards: Dysfunction of cell signalling in the aging brain: implication in brain metabolism and behaviour, Molecular mechanisms of initiation and regulation of reactive astrogliosis, Alliance for Life Sciences: From Strategies to Actions in Central and Eastern Europe, Alliance4Life Bridging the Research and Innovation Gap in Life Sciences, Molecular mechanisms of specificity in regulation of secretion and action of muscle-derived cytokines
OpenAlex ID: W4417247109