Work

Author response: General trends in the calnexin-dependent expression and pharmacological rescue of clinical CFTR variants

Year: 2025

Type: peer-review

Abstract: Combining deep mutational scanning with CRISPR, interactome measurements, and electrophysiology reveals nuanced effects of the lectin chaperone calnexin on the pharmacological properties of 232 cystic fibrosis variants.

Source: eLife

DOI: 10.7554/elife.107180.3.sa3

Authors: Austin Tedman, John A Olson, Minsoo Kim, Catherine Foye, JaNise J Jackson, Eli F McDonald, Andrew G McKee, Karen Noguera, Charles P Kuntz, Jens Meiler, Kathryn E Oliver, Lars Plate, Jonathan P Schlebach

Institutions: Purdue University West Lafayette, Vanderbilt University, Emory University, Indiana University Bloomington

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4417247883

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