Behavioural changes in exposure patterns after genetic counselling among asymptomatic first-degree relatives of patients with pulmonary fibrosis and carriers of a telomere-related gene variant
Year: 2025
Type: article
Study design: Observational Study
Abstract: Extract Exposure to tobacco and profibrotic agents contributes to pulmonary fibrosis in relatives of patients carrying a telomere-related gene (TRG) variant [1]. Relatives may know their genetic status in cascade testing, and most of them don't report regret of having genetic testing whatever the results [2]. We hypothesized that the results of genetic cascade testing induces/triggers behavioral changes regarding environmental exposures. The study aims to describe past and current exposures among relatives of patients carrying a TRG variant and to compare behavior changes between carriers and non-carriers after genetic counselling.
Source: ERJ Open Research
Institutions: Inserm, Université Sorbonne Paris Nord, Assistance Publique – Hôpitaux de Paris, Hôpital Avicenne, Université Paris Cité, Centre de Recherche sur l'Inflammation, Hôpital Bichat-Claude-Bernard, Centre Hospitalier Universitaire de Lille, Institut de Recherche en Santé, Environnement et Travail, Hôpital Pontchaillou, Centre Hospitalier Universitaire de Rennes, Université de Rennes, Hôpital Larrey, CHU Dijon Bourgogne, Centre de recherche Translationnelle en Médecine moléculaire, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Hôpital Louis Pradel, Hôpital Armand-Trousseau
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $808
Funder: Agence Nationale de la Recherche
OpenAlex ID: W4417252045