Year: 2025
Type: article
Abstract: A simple, efficient, and environmentally friendly methodology for the dibromination of anisoles using Fe(NO3)3·9H2O/FeBr3 at room temperature was developed. In general, anisoles bearing electron-donating or weak electron-withdrawing groups gave the dibrominated product in good to excellent yields, while anisoles bearing a strong electron-withdrawing group gave a high yield of the monobromination product. This protocol was also suitable for the bromination of 2- or 4-substituted substrates. Importantly, this protocol was also applicable for gram-scale synthesis. It is hopeful that this methodology will have great use in organic synthesis.
Source: SynOpen
DOI: 10.1055/a-2769-2826
Authors: Wenfei Yang, Caicui Li, Xiaodan Wang, Yiying Li, Jinhui Wang, Huanjun Xu, Zhengtao Huang, Xinmei Wang, Wubo Wan, Lijuan Wang
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $340
OpenAlex ID: W4417258626